From: Subject: OBA / Faculty / Christopher Lowe Date: Fri, 18 Sep 2009 12:45:33 -0400 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01CA385D.E98C9920" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01CA385D.E98C9920 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://pondside.uchicago.edu/oba/faculty/lowe_c.html OBA / Faculty / Christopher Lowe

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Christopher Lowe, PhD

Assistant Professor
Department of = Organismal Biology and Anatomy

Office: Anatomy 301
Department of = Organismal=20 Biology and Anatomy
University of Chicago
1027 E. 57th = St.
Chicago, IL 60637

Tel. (773) = 702-4226
Fax.=20 (773) 702-0037
Email:

3D"Christopher =20

Lowe Group Links:
Lab = Website

Research Interests

My lab's research interests are in the field of evolution = and=20 development, and more specifically the evolution of the=20 deuterostomes. This major metazoan lineage is made up of = four major=20 groups; chordates, echinoderms, hemichordates, and a very = recent=20 addition; Xenoturbellida . The early evolutionary history of = the=20 deuterostomes remains poorly understood and surprisingly = even the=20 evolutionary origins of our own phylum, the chordates, = remains a=20 major puzzle for zoologists. This uncertainty is partly due = to a=20 poor early fossil record for this lineage, but also due to = the=20 enormous morphological disparity in adult body plans between = the=20 major groups. Reconstructing the body plan of a plausible = common=20 ancestor based on extant forms is fraught with difficulties. = My work=20 attempts to make some headway in this area, and has focused = on=20 investigating the role of developmental genes that underlie = these=20 divergent body plans and morphologies in hemichordates and=20 echinoderms. By comparing the expression and roles of these = genes to=20 their orthologues in chordates I am trying to gain insights = into=20 early events in deuterostome evolution.

We have largely focused on the origins and early = evolution of the=20 vertebrate brain and central nervous system. While the brain = is=20 clearly a key innovation of our phylum, we understand very = little=20 about its evolutionary origins outside of the chordates. = Much=20 progress has been made in identifying the early molecular = genetic=20 program of brain patterning and morphogenesis in vertebrate = model=20 systems. We have been developing the hemichordate = Saccoglossus=20 kowalevskii as a less complex developmental model for = addressing=20 early evolution and origins of the vertebrate nervous = system. As a=20 phylum closely related to chordates, hemichordates are the = most=20 promising group for addressing issues of chordate brain = evolution=20 and development. Unlike chordates, their nervous system is = organized=20 on the basis of a nerve net rather than a centralized = structure. We=20 have been investigating conserved gene regulatory networks = involved=20 in the regionalization of the vertebrate brain during = hemichordate=20 development and find a remarkable conservation of gene = expression=20 despite the organizational disparity between the nervous = systems of=20 both groups. By this comparative approach, we are further = developing=20 this work to determine what aspects of central nervous = system=20 patterning predate the spectacular morphological elaboration = of the=20 vertebrate brain, and were present in the common ancestor of = hemichordates and chordates.

More recently we have begun two new lines of = research:

1. The evolution of mesoderm.

2. Evolution of asymmetry within the deuterostomes.

For more information on Evolution and Development at The=20 University of Chicago go to http://www.ucevodevo.uchicago= .edu/.

<= IMG=20 class=3Dborderphoto=20 = src=3D"http://pondside.uchicago.edu/oba/faculty/lowe/img/RX-4.gif"=20 border=3D0>

Selected Publications

Lowe C.J., Wu M, Salic, A., Evans, L., Lander E., = Stange-Thomann,=20 N., Gruber, C., Gerhart, J., Kirschner, M. (2003) = Anteroposterior=20 Patterning in Hemichordates and the Origins of the Chordate = Nervous=20 System. Cell 113, 853-865. (PubMed)

Gerhart, J. Lowe, CJ., Kirschner M. Hemichordates and = origin of=20 chordates. (2005) Curr Opin Genet Dev. 15(4):461-7. (PubMed)

Lowe C. J., Terasaki M., Wu, M., Freeman, R.M. Jr., = Runft, L.,=20 Kwan, K., Haigo, S., Aronowicz, J., Lander E., Gruber, C., = Smith,=20 M., Kirschner, M., Gerhart, J. (2006) Dorsoventral = patterning in=20 hemichordates: insights into early chordate evolution. PLoS = Biol.=20 Sep;4(9). (PubMed)=20

Aronowicz J, and Lowe C.J. Hox gene expression in the=20 hemichordate S. kowalevskii and the evolution of = deuterostome=20 nervous systems. (2006) Integrative and Comparative Biology. = ePUB=20 Oct18.

Bourlat SJ, Juliusdottir T, Lowe CJ, Freeman R, Aronowicz = J,=20 Kirschner M, Lander ES, Thorndyke M, Nakano H, Kohn AB, = Heyland A,=20 Moroz LL, Copley RR, Telford MJ. (2006) Dueterostome = phylogeny=20 reveals monophyletic chordates and the new phylum = Xenoturbellida.=20 Nature. Nov 2:444(7115): 85-8. (PubMed)

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=20 =A9 2007 Department of Organismal Biology and Anatomy
=AE The = University of=20 Chicago
1027 E 57th St, Chicago, IL 60637
Phone: = 773-702-8087 | Fax:=20 773-702-0037 | Email

web=20 design ::

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} #bodytext A:hover { FONT-WEIGHT: bold; TEXT-DECORATION: underline } .borderall { BORDER-RIGHT: #999999 1px solid; PADDING-RIGHT: 1px; BORDER-TOP: = #999999 1px solid; PADDING-LEFT: 1px; PADDING-BOTTOM: 1px; BORDER-LEFT: = #999999 1px solid; PADDING-TOP: 1px; BORDER-BOTTOM: #999999 1px solid } .bordert { BORDER-RIGHT: #999999 1px; BORDER-TOP: #999999 1px solid; BORDER-LEFT: = #999999 1px; BORDER-BOTTOM: #999999 1px } .borderlb { BORDER-RIGHT: #999999 1px; BORDER-TOP: #999999 1px; BORDER-LEFT: = #999999 1px dotted; BORDER-BOTTOM: #999999 1px dotted } .borderltr { BORDER-RIGHT: #999999 1px dotted; BORDER-TOP: #999999 1px dotted; = BORDER-LEFT: #999999 1px dotted; BORDER-BOTTOM: #999999 1px } .borderb { BORDER-RIGHT: #999999 1px; BORDER-TOP: #999999 1px; BORDER-LEFT: = #999999 1px; BORDER-BOTTOM: #999999 1px solid } .intermtext { PADDING-RIGHT: 10px; FONT-SIZE: 10px; PADDING-BOTTOM: 5px; COLOR: = #333333; LINE-HEIGHT: 14px; FONT-FAMILY: Verdana, Arial, Helvetica, = sans-serif; TEXT-ALIGN: right } .borderimage { BORDER-RIGHT: #cccccc 1px solid; BORDER-TOP: #cccccc 1px solid; = MARGIN-BOTTOM: 25px; MARGIN-LEFT: 25px; BORDER-LEFT: #cccccc 1px solid; = BORDER-BOTTOM: #cccccc 1px solid } .borderphoto { BORDER-RIGHT: #999999 1px solid; PADDING-RIGHT: 1px; BORDER-TOP: = #999999 1px solid; PADDING-LEFT: 1px; PADDING-BOTTOM: 1px; BORDER-LEFT: = #999999 1px solid; PADDING-TOP: 1px; BORDER-BOTTOM: #999999 1px solid; = BACKGROUND-COLOR: #ffffff } .borderphotobig { BORDER-RIGHT: #999999 1px solid; PADDING-RIGHT: 1px; BORDER-TOP: = #999999 1px solid; PADDING-LEFT: 1px; PADDING-BOTTOM: 1px; MARGIN-LEFT: = 15px; BORDER-LEFT: #999999 1px solid; PADDING-TOP: 1px; BORDER-BOTTOM: = #999999 1px solid; BACKGROUND-COLOR: #ffffff } .borderphotosmall { BORDER-RIGHT: #999999 1px solid; PADDING-RIGHT: 1px; BORDER-TOP: = #999999 1px solid; PADDING-LEFT: 1px; FLOAT: left; MARGIN-BOTTOM: 10px; = PADDING-BOTTOM: 1px; BORDER-LEFT: #999999 1px solid; MARGIN-RIGHT: 25px; = PADDING-TOP: 1px; BORDER-BOTTOM: #999999 1px solid; BACKGROUND-COLOR: = #ffffff } .intermtext2 { PADDING-LEFT: 0px; FONT-SIZE: 9px; PADDING-BOTTOM: 5px; COLOR: #333333; = LINE-HEIGHT: 14px; PADDING-TOP: 0px; FONT-FAMILY: Verdana, Arial, = Helvetica, sans-serif; TEXT-ALIGN: right } .borderlr { BORDER-RIGHT: #666666 1px solid; BORDER-TOP: #666666 1px; BORDER-LEFT: = #666666 1px solid; BORDER-BOTTOM: #666666 1px } .borderr { BORDER-RIGHT: #ffffff 1px solid; BORDER-TOP: #ffffff 1px; BORDER-LEFT: = #ffffff 1px; BORDER-BOTTOM: #ffffff 1px } .borderpage { BORDER-RIGHT: #999999 1px solid; PADDING-RIGHT: 1px; BORDER-TOP: 0px; = PADDING-LEFT: 1px; PADDING-BOTTOM: 1px; BORDER-LEFT: #999999 1px solid; = BORDER-BOTTOM: #999999 1px solid } .bodytextbold { FONT-WEIGHT: bold; FONT-SIZE: 10px; COLOR: #012f43; LINE-HEIGHT: 15px; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } .bordrerl { BORDER-RIGHT: #999999 1px; BORDER-TOP: #999999 1px; BORDER-LEFT: = #999999 1px dotted; BORDER-BOTTOM: #999999 1px } .bordtr { BORDER-RIGHT: #999999 1px dotted; BORDER-TOP: #999999 1px dotted; = BORDER-LEFT: #999999 1px; BORDER-BOTTOM: #999999 1px } .header4 { FONT-WEIGHT: bold; FONT-SIZE: 11px; COLOR: #003366; LINE-HEIGHT: 18px; = FONT-FAMILY: Verdana, Arial, Helvetica, sans-serif } ------=_NextPart_000_0000_01CA385D.E98C9920--